Do lockdowns and mobility restrictions contain the spread of COVID-19? Data was collected on district-level non-pharmaceutical interventions, using government notifications and news reports, in six major Indian states to assess the impact of NPIs on COVID-19 transmission and fatality in 2020. Findings suggest that NPIs slowed COVID-19 death rates in Tamil Nadu, Karnataka, and Andhra Pradesh. Interventions that were most associated with slowing fatalities were temple closures, retail closures, and curfews. Even with incomplete compliance, limiting mass gatherings in face of incipient viral waves may save lives.